In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003]
Transcription factors with Perturb-seq knockdown data for NKD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NKD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NKD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:50,368,327–50,369,672 | 179.4 kb | Distal (>10kb) Multiome HiCAR | 596 | |
| chr16:50,467,766–50,468,772 | 80.2 kb | Distal (>10kb) Multiome | 685 | |
| chr16:50,539,882–50,540,391 | 8.3 kb | Proximal (<10kb) Multiome | 134 | |
| chr16:50,547,325–50,549,168 | 105 bp | At TSS Multiome | 774 | |
| chr16:50,665,176–50,665,840 | 117.1 kb | Distal (>10kb) Multiome HiCAR | 469 | |
| chr16:50,741,394–50,742,754 | 193.6 kb | Distal (>10kb) Multiome | 739 | |
| chr16:50,806,109–50,806,812 | 258.1 kb | Distal (>10kb) Multiome | 521 |
Genomic view of the NKD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.