Predicted to enable calcium ion binding activity. Predicted to be involved in cell differentiation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NHSL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NHSL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NHSL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:71,910,031–71,910,207 | 636 bp | At TSS | 41 | |
| chrX:71,910,545–71,912,028 | 567 bp | At TSS Multiome | 258 | |
| chrX:71,957,980–71,958,453 | 47.2 kb | Distal (>10kb) Multiome | 90 | |
| chrX:72,018,244–72,018,883 | 107.8 kb | Distal (>10kb) Multiome | 577 | |
| chrX:72,115,329–72,115,816 | 204.7 kb | Distal (>10kb) Multiome | 75 | |
| chrX:72,131,595–72,132,294 | 221.2 kb | Distal (>10kb) Multiome | 266 | |
| chrX:72,181,219–72,182,040 | 270.7 kb | Distal (>10kb) Multiome | 619 |
Genomic view of the NHSL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.