Predicted to be involved in cell differentiation. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NHSL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NHSL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NHSL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:138,240,458–138,241,750 | 331.3 kb | Distal (>10kb) Multiome | 180 | |
| chr6:138,331,206–138,332,418 | 240.8 kb | Distal (>10kb) Multiome | 260 | |
| chr6:138,403,215–138,405,244 | 168.3 kb | Distal (>10kb) Multiome | 1060 | |
| chr6:138,485,936–138,486,779 | 86.3 kb | Distal (>10kb) Multiome | 199 | |
| chr6:138,499,301–138,499,693 | at TSS | At TSS | 436 | |
| chr6:138,535,879–138,536,299 | 9.4 kb | Proximal (<10kb) | 33 | |
| chr6:138,545,586–138,545,987 | at TSS | At TSS | 286 | |
| chr6:138,555,438–138,556,036 | 9.7 kb | Proximal (<10kb) | 303 | |
| chr6:138,563,656–138,564,006 | 8.5 kb | Proximal (<10kb) | 131 | |
| chr6:138,572,302–138,572,772 | at TSS | At TSS | 576 | |
| chr6:138,691,712–138,693,955 | 120.8 kb | Distal (>10kb) Multiome | 807 | |
| chr6:138,772,879–138,774,086 | 201.1 kb | Distal (>10kb) Multiome | 833 | |
| chr6:138,795,674–138,796,576 | 223.5 kb | Distal (>10kb) Multiome | 181 | |
| chr6:138,817,772–138,818,464 | 245.6 kb | Distal (>10kb) Multiome | 321 |
Genomic view of the NHSL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.