NFKBID

NFKB inhibitor delta | IkBNS, IkappaBNS, TA-NFKBH

Predicted to enable NF-kappaB binding activity. Predicted to be involved in T cell receptor signaling pathway; positive regulation of T-helper 17 cell differentiation; and regulation of gene expression. Predicted to act upstream of or within several processes, including negative regulation of NF-kappaB transcription factor activity; negative regulation of canonical NF-kappaB signal transduction; and positive regulation of thymocyte apoptotic process. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 6 terms

T cell receptor signaling pathway (GO:0050852)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of T-helper 17 cell differentiation (GO:2000321)protein binding (GO:0005515)regulation of gene expression (GO:0010468)

Expression (TPM)

TFs regulating NFKBID 0 TFs

Transcription factors with Perturb-seq knockdown data for NFKBID. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NFKBID upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to NFKBID

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NFKBID, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:35,612,546–35,613,176	287.8 kb	Distal (>10kb) Multiome	778
chr19:35,628,465–35,629,474	271.7 kb	Distal (>10kb) Multiome	889
chr19:35,641,602–35,642,192	258.8 kb	Distal (>10kb) Multiome	183
chr19:35,643,064–35,645,730	257.0 kb	Distal (>10kb) Multiome	1010
chr19:35,648,040–35,648,575	252.3 kb	Distal (>10kb) Multiome	599
chr19:35,673,179–35,673,643	227.1 kb	Distal (>10kb) Multiome	311
chr19:35,702,152–35,702,985	198.0 kb	Distal (>10kb) Multiome	662
chr19:35,716,025–35,718,811	182.8 kb	Distal (>10kb) Multiome	1018
chr19:35,740,083–35,741,430	159.7 kb	Distal (>10kb) Multiome	829
chr19:35,744,481–35,746,086	155.3 kb	Distal (>10kb) Multiome	679
chr19:35,748,170–35,749,017	152.1 kb	Distal (>10kb) Multiome	749
chr19:35,757,432–35,758,657	142.4 kb	Distal (>10kb) Multiome	851
chr19:35,767,601–35,768,256	132.6 kb	Distal (>10kb) Multiome	276
chr19:35,775,066–35,776,063	125.1 kb	Distal (>10kb) Multiome	474
chr19:35,784,357–35,785,306	115.8 kb	Distal (>10kb) Multiome	183
chr19:35,860,621–35,861,651	39.3 kb	Distal (>10kb) Multiome	299
chr19:35,868,369–35,868,860	32.1 kb	Distal (>10kb) Multiome	320
chr19:35,869,343–35,870,482	30.6 kb	Distal (>10kb) Multiome	492
chr19:35,899,240–35,900,760	861 bp	At TSS Multiome	751
chr19:35,903,611–35,903,977	3.9 kb	Proximal (<10kb)	481
chr19:35,931,342–35,932,167	31.1 kb	Distal (>10kb) Multiome	835
chr19:35,936,083–35,936,704	35.9 kb	Distal (>10kb) Multiome	417
chr19:35,986,945–35,987,622	86.7 kb	Distal (>10kb) Multiome	363
chr19:35,994,796–35,995,940	94.6 kb	Distal (>10kb) Multiome	897
chr19:36,008,519–36,009,006	108.3 kb	Distal (>10kb) Multiome	427
chr19:36,013,972–36,014,810	113.8 kb	Distal (>10kb) Multiome	623
chr19:36,032,424–36,033,187	132.3 kb	Distal (>10kb) Multiome	179
chr19:36,053,782–36,055,591	153.9 kb	Distal (>10kb) Multiome	1026
chr19:36,113,981–36,116,196	214.7 kb	Distal (>10kb) Multiome	1052
chr19:36,127,575–36,128,707	227.5 kb	Distal (>10kb) Multiome	942
chr19:36,139,425–36,141,811	240.8 kb	Distal (>10kb) Multiome	1037
chr19:36,160,493–36,161,405	260.4 kb	Distal (>10kb) Multiome	94
chr19:37,691,873–37,692,535	1791.8 kb	Distal (>10kb) Multiome HiCAR	609

Genome Browser

Genomic view of the NFKBID locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.