The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]
Transcription factors with Perturb-seq knockdown data for NFKBIB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NFKBIB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NFKBIB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:38,394,369–38,395,035 | 505.3 kb | Distal (>10kb) Multiome HiCAR | 191 | |
| chr19:38,402,504–38,403,738 | 496.9 kb | Distal (>10kb) Multiome HiCAR | 940 | |
| chr19:38,417,766–38,418,568 | 481.9 kb | Distal (>10kb) Multiome HiCAR | 407 | |
| chr19:38,506,710–38,507,745 | 392.7 kb | Distal (>10kb) Multiome HiCAR | 369 | |
| chr19:38,514,956–38,515,568 | 384.7 kb | Distal (>10kb) Multiome HiCAR | 404 | |
| chr19:38,595,857–38,597,322 | 303.6 kb | Distal (>10kb) Multiome HiCAR | 478 | |
| chr19:38,617,752–38,619,569 | 281.0 kb | Distal (>10kb) Multiome | 835 | |
| chr19:38,647,137–38,648,653 | 252.4 kb | Distal (>10kb) Multiome | 856 | |
| chr19:38,666,103–38,666,668 | 233.7 kb | Distal (>10kb) Multiome | 317 | |
| chr19:38,683,677–38,684,144 | 216.3 kb | Distal (>10kb) Multiome | 678 | |
| chr19:38,734,491–38,735,702 | 164.6 kb | Distal (>10kb) Multiome | 338 | |
| chr19:38,735,981–38,737,634 | 162.9 kb | Distal (>10kb) Multiome HiCAR | 493 | |
| chr19:38,754,913–38,755,455 | 144.8 kb | Distal (>10kb) Multiome | 12 | |
| chr19:38,831,191–38,832,119 | 68.1 kb | Distal (>10kb) Multiome | 931 | |
| chr19:38,849,166–38,852,789 | 47.9 kb | Distal (>10kb) Multiome | 1139 | |
| chr19:38,869,729–38,870,536 | 29.9 kb | Distal (>10kb) Multiome | 350 | |
| chr19:38,899,267–38,900,530 | 123 bp | At TSS Multiome | 886 | |
| chr19:38,930,044–38,931,363 | 30.8 kb | Distal (>10kb) Multiome | 889 | |
| chr19:38,949,549–38,950,582 | 49.9 kb | Distal (>10kb) Multiome | 330 | |
| chr19:38,975,192–38,976,859 | 76.7 kb | Distal (>10kb) Multiome | 846 | |
| chr19:38,995,916–38,996,388 | 96.2 kb | Distal (>10kb) Multiome | 144 | |
| chr19:39,030,958–39,033,042 | 131.6 kb | Distal (>10kb) Multiome | 763 | |
| chr19:39,125,485–39,126,290 | 225.8 kb | Distal (>10kb) Multiome | 866 |
Genomic view of the NFKBIB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.