NFE2L3

NFE2 like bZIP transcription factor 3 | Nrf3

This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18. [provided by RefSeq, Mar 2009]

Member of: DE-9 Developmental clusters: GC4

Biological processes 20 terms

DNA binding (GO:0003677)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)chromatin (GO:0000785)integrated stress response signaling (GO:0140467)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)transcription by RNA polymerase II (GO:0006366)

Expression (TPM)

TFs regulating NFE2L3 0 TFs

Transcription factors with Perturb-seq knockdown data for NFE2L3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NFE2L3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to NFE2L3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NFE2L3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr7:25,854,641–25,855,390	297.1 kb	Distal (>10kb) Multiome	404
chr7:25,856,491–25,858,198	295.1 kb	Distal (>10kb) Multiome	687
chr7:25,861,814–25,863,111	289.6 kb	Distal (>10kb) Multiome	616
chr7:25,950,166–25,951,811	200.9 kb	Distal (>10kb) Multiome	777
chr7:26,151,798–26,154,281	14 bp	At TSS Multiome	635
chr7:26,155,597–26,156,063	3.4 kb	Proximal (<10kb)	142
chr7:26,199,573–26,202,470	48.8 kb	Distal (>10kb) Multiome	1167
chr7:26,291,673–26,292,388	139.7 kb	Distal (>10kb) Multiome	647
chr7:26,375,964–26,377,507	224.9 kb	Distal (>10kb) Multiome	698
chr7:26,397,280–26,399,477	246.4 kb	Distal (>10kb) Multiome	678

Genome Browser

Genomic view of the NFE2L3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.