NEMF

nuclear export mediator factor | FLJ10051, NY-CO-1, RQC2, SDCCAG1

This gene encodes a component of the ribosome quality control complex. The encoded protein facilitates the recognition and ubiquitination of stalled 60S subunits by the ubiquitin ligase listerin. A similar protein in fly functions as a tumor suppressor. [provided by RefSeq, Jul 2016]

Member of: DE-2 DE-2.2

Biological processes 22 terms

CAT tailing (GO:0140708)CAT tailing (GO:0140708)RQC complex (GO:1990112)RQC complex (GO:1990112)alpha-aminoacyl-tRNA binding (GO:1904678)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)cytosolic ribosome (GO:0022626)nuclear export (GO:0051168)nucleus (GO:0005634)protein-containing complex assembly (GO:0065003)rescue of stalled cytosolic ribosome (GO:0072344)rescue of stalled cytosolic ribosome (GO:0072344)rescue of stalled cytosolic ribosome (GO:0072344)ribosomal large subunit binding (GO:0043023)ribosomal large subunit binding (GO:0043023)ribosome-associated ubiquitin-dependent protein catabolic process (GO:1990116)ribosome-associated ubiquitin-dependent protein catabolic process (GO:1990116)ribosome-associated ubiquitin-dependent protein catabolic process (GO:1990116)ribosome-associated ubiquitin-dependent protein catabolic process (GO:1990116)tRNA binding (GO:0000049)

Expression (TPM)

TFs regulating NEMF 0 TFs

Transcription factors with Perturb-seq knockdown data for NEMF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NEMF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to NEMF

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NEMF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr14:49,585,877–49,587,282	245.7 kb	Distal (>10kb) Multiome	966
chr14:49,598,179–49,599,418	233.4 kb	Distal (>10kb) Multiome	967
chr14:49,620,144–49,621,897	211.5 kb	Distal (>10kb) Multiome	930
chr14:49,633,485–49,635,896	197.9 kb	Distal (>10kb) Multiome HiCAR	1040
chr14:49,687,569–49,688,718	144.0 kb	Distal (>10kb) Multiome	843
chr14:49,692,914–49,693,633	138.9 kb	Distal (>10kb) Multiome	764
chr14:49,767,430–49,769,102	64.2 kb	Distal (>10kb) Multiome	899
chr14:49,852,270–49,853,410	20.6 kb	Distal (>10kb) Multiome	813
chr14:49,853,662–49,854,089	21.7 kb	Distal (>10kb) Multiome	439
chr14:49,861,592–49,863,464	30.7 kb	Distal (>10kb) Multiome	1038
chr14:49,867,745–49,868,682	36.0 kb	Distal (>10kb) Multiome	699
chr14:49,892,363–49,894,019	60.7 kb	Distal (>10kb) Multiome	981
chr14:50,000,183–50,001,939	169.1 kb	Distal (>10kb) Multiome	669
chr14:50,116,214–50,116,984	284.4 kb	Distal (>10kb) Multiome	818

Genome Browser

Genomic view of the NEMF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.