NEK8

NIMA related kinase 8 | NPHP9

This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans. [provided by RefSeq, Jul 2008]

Biological processes 23 terms

ATP binding (GO:0005524)animal organ development (GO:0048513)animal organ morphogenesis (GO:0009887)axoneme (GO:0005930)centrosome (GO:0005813)ciliary base (GO:0097546)ciliary inversin compartment (GO:0097543)cilium (GO:0005929)cilium (GO:0005929)cilium (GO:0005929)cilium (GO:0005929)cilium (GO:0005929)cytoplasm (GO:0005737)cytoskeleton (GO:0005856)determination of left/right symmetry (GO:0007368)heart development (GO:0007507)protein binding (GO:0005515)protein kinase activity (GO:0004672)protein serine kinase activity (GO:0106310)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)regulation of hippo signaling (GO:0035330)regulation of hippo signaling (GO:0035330)

Expression (TPM)

TFs regulating NEK8 0 TFs

Transcription factors with Perturb-seq knockdown data for NEK8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NEK8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to NEK8

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NEK8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:28,466,531–28,467,034	259.1 kb	Distal (>10kb) Multiome	179
chr17:28,551,965–28,553,140	173.3 kb	Distal (>10kb) Multiome	557
chr17:28,570,861–28,571,983	154.3 kb	Distal (>10kb) Multiome	701
chr17:28,576,649–28,577,524	148.9 kb	Distal (>10kb) Multiome	652
chr17:28,598,491–28,599,842	126.8 kb	Distal (>10kb) Multiome	810
chr17:28,621,936–28,622,562	103.5 kb	Distal (>10kb) Multiome	55
chr17:28,644,541–28,645,596	80.7 kb	Distal (>10kb) Multiome	795
chr17:28,661,635–28,662,527	63.8 kb	Distal (>10kb) Multiome	809
chr17:28,710,720–28,712,813	14.5 kb	Distal (>10kb) Multiome	892
chr17:28,717,030–28,718,784	8.0 kb	Proximal (<10kb) Multiome	492
chr17:28,718,918–28,720,313	6.1 kb	Proximal (<10kb) Multiome	927
chr17:28,724,652–28,729,474	1.1 kb	Proximal (<10kb) Multiome	1286
chr17:28,743,083–28,744,926	18.2 kb	Distal (>10kb) Multiome	991
chr17:28,745,076–28,746,436	19.7 kb	Distal (>10kb) Multiome	568
chr17:28,749,859–28,750,549	24.3 kb	Distal (>10kb) Multiome	550
chr17:28,811,615–28,812,945	86.6 kb	Distal (>10kb) Multiome	699
chr17:28,842,307–28,843,098	116.9 kb	Distal (>10kb) Multiome	717
chr17:28,854,460–28,855,289	129.0 kb	Distal (>10kb) Multiome	780
chr17:28,896,962–28,898,028	171.7 kb	Distal (>10kb) Multiome	846
chr17:28,902,302–28,903,488	177.1 kb	Distal (>10kb) Multiome HiCAR	967
chr17:28,950,281–28,952,708	225.8 kb	Distal (>10kb) Multiome	989
chr17:28,984,463–28,984,954	258.7 kb	Distal (>10kb) Multiome	33
chr17:28,985,971–28,986,457	260.3 kb	Distal (>10kb) Multiome	123
chr17:29,005,841–29,006,414	280.2 kb	Distal (>10kb) Multiome	707

Genome Browser

Genomic view of the NEK8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.