NEK6

NIMA related kinase 6 | SID6-1512

The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Member of: DE-10

Biological processes 45 terms

ATP binding (GO:0005524)ATP binding (GO:0005524)DNA-binding transcription factor binding (GO:0140297)centriolar satellite (GO:0034451)centrosome (GO:0005813)centrosome (GO:0005813)chromosome segregation (GO:0007059)chromosome segregation (GO:0007059)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)kinesin binding (GO:0019894)magnesium ion binding (GO:0000287)mitotic nuclear membrane disassembly (GO:0007077)mitotic spindle organization (GO:0007052)nuclear speck (GO:0016607)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)peptidyl-serine phosphorylation (GO:0018105)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)protein autophosphorylation (GO:0046777)protein binding (GO:0005515)protein kinase activity (GO:0004672)protein kinase binding (GO:0019901)protein phosphorylation (GO:0006468)protein serine kinase activity (GO:0106310)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein-containing complex (GO:0032991)regulation of cellular senescence (GO:2000772)regulation of chromosome organization (GO:0033044)regulation of mitotic cell cycle (GO:0007346)regulation of mitotic cell cycle (GO:0007346)regulation of mitotic metaphase/anaphase transition (GO:0030071)regulation of mitotic metaphase/anaphase transition (GO:0030071)spindle assembly (GO:0051225)spindle assembly (GO:0051225)spindle pole (GO:0000922)transcription corepressor binding (GO:0001222)ubiquitin protein ligase binding (GO:0031625)

Expression (TPM)

TFs regulating NEK6 0 TFs

Transcription factors with Perturb-seq knockdown data for NEK6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NEK6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to NEK6

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NEK6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr9:124,008,456–124,009,293	249.1 kb	Distal (>10kb) Multiome	302
chr9:124,010,900–124,012,625	246.4 kb	Distal (>10kb) Multiome	465
chr9:124,040,710–124,041,459	216.8 kb	Distal (>10kb) Multiome	331
chr9:124,257,674–124,258,314	47 bp	At TSS Multiome	374
chr9:124,258,508–124,258,918	560 bp	At TSS	410
chr9:124,415,161–124,415,813	157.5 kb	Distal (>10kb) Multiome	779
chr9:124,419,615–124,420,013	161.7 kb	Distal (>10kb) Multiome	266
chr9:124,449,997–124,450,901	192.5 kb	Distal (>10kb) Multiome	232
chr9:124,453,124–124,454,077	195.7 kb	Distal (>10kb) Multiome	218
chr9:124,477,322–124,478,654	220.0 kb	Distal (>10kb) Multiome	223
chr9:124,482,335–124,482,814	224.7 kb	Distal (>10kb) Multiome	94
chr9:124,504,291–124,505,297	247.1 kb	Distal (>10kb) Multiome	187

Genome Browser

Genomic view of the NEK6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.