NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for NEIL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NEIL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NEIL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:177,309,505–177,310,535 | 117 bp | At TSS Multiome | 707 | |
| chr4:177,380,669–177,381,553 | 71.2 kb | Distal (>10kb) Multiome | 346 | |
| chr4:177,440,910–177,443,148 | 132.5 kb | Distal (>10kb) Multiome | 1022 | |
| chr4:177,444,830–177,445,755 | 135.2 kb | Distal (>10kb) Multiome | 245 | |
| chr4:177,504,861–177,506,078 | 195.6 kb | Distal (>10kb) Multiome | 235 |
Genomic view of the NEIL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.