The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Transcription factors with Perturb-seq knockdown data for NEDD9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NEDD9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NEDD9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:11,007,370–11,008,733 | 224.6 kb | Distal (>10kb) Multiome | 412 | |
| chr6:11,043,323–11,045,047 | 188.2 kb | Distal (>10kb) Multiome | 766 | |
| chr6:11,093,116–11,094,741 | 138.9 kb | Distal (>10kb) Multiome | 1088 | |
| chr6:11,229,067–11,229,994 | 3.2 kb | Proximal (<10kb) Multiome | 412 | |
| chr6:11,231,826–11,233,562 | 39 bp | At TSS Multiome | 894 | |
| chr6:11,241,566–11,242,171 | 9.2 kb | Proximal (<10kb) Multiome | 497 |
Genomic view of the NEDD9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.