Predicted to enable NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. Part of respiratory chain complex I. Implicated in nuclear type mitochondrial complex I deficiency. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NDUFC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NDUFC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NDUFC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:77,819,354–77,821,704 | 258.8 kb | Distal (>10kb) Multiome | 1047 | |
| chr11:77,994,042–77,995,347 | 85.0 kb | Distal (>10kb) Multiome | 908 | |
| chr11:78,022,454–78,023,411 | 56.7 kb | Distal (>10kb) Multiome | 526 | |
| chr11:78,079,393–78,080,040 | 54 bp | At TSS Multiome | 1033 | |
| chr11:78,139,106–78,140,207 | 59.8 kb | Distal (>10kb) Multiome | 842 | |
| chr11:78,187,536–78,189,464 | 108.8 kb | Distal (>10kb) Multiome | 905 | |
| chr11:78,365,205–78,365,789 | 285.6 kb | Distal (>10kb) Multiome | 332 |
Genomic view of the NDUFC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.