Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone and proton motive force-driven mitochondrial ATP synthesis. Located in mitochondrial inner membrane. Part of respiratory chain complex I. Implicated in nuclear type mitochondrial complex I deficiency 32. Biomarker of Alzheimer's disease and Parkinson's disease. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NDUFB8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NDUFB8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NDUFB8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:100,228,957–100,229,948 | 300.3 kb | Distal (>10kb) Multiome | 759 | |
| chr10:100,267,386–100,267,986 | 262.2 kb | Distal (>10kb) Multiome | 715 | |
| chr10:100,286,018–100,287,021 | 243.3 kb | Distal (>10kb) Multiome | 849 | |
| chr10:100,346,401–100,347,640 | 183.0 kb | Distal (>10kb) Multiome | 919 | |
| chr10:100,359,067–100,359,724 | 170.6 kb | Distal (>10kb) Multiome | 425 | |
| chr10:100,372,854–100,374,386 | 156.4 kb | Distal (>10kb) Multiome | 964 | |
| chr10:100,481,576–100,482,049 | 48.2 kb | Distal (>10kb) Multiome | 298 | |
| chr10:100,482,268–100,483,078 | 47.1 kb | Distal (>10kb) Multiome | 497 | |
| chr10:100,485,778–100,486,586 | 43.8 kb | Distal (>10kb) Multiome | 161 | |
| chr10:100,518,832–100,519,948 | 10.4 kb | Distal (>10kb) Multiome | 417 | |
| chr10:100,529,444–100,530,236 | 3 bp | At TSS Multiome | 619 | |
| chr10:100,535,502–100,536,234 | 6.0 kb | Proximal (<10kb) Multiome | 759 | |
| chr10:100,561,994–100,562,629 | 32.3 kb | Distal (>10kb) Multiome | 491 | |
| chr10:100,654,597–100,655,452 | 125.2 kb | Distal (>10kb) Multiome | 300 | |
| chr10:100,656,014–100,657,003 | 126.8 kb | Distal (>10kb) Multiome | 310 | |
| chr10:100,670,865–100,671,507 | 141.2 kb | Distal (>10kb) Multiome | 364 | |
| chr10:100,680,805–100,681,542 | 151.1 kb | Distal (>10kb) Multiome | 636 | |
| chr10:100,715,555–100,715,963 | 186.0 kb | Distal (>10kb) Multiome | 117 | |
| chr10:100,729,074–100,730,178 | 199.6 kb | Distal (>10kb) Multiome | 304 | |
| chr10:100,739,174–100,740,373 | 209.9 kb | Distal (>10kb) Multiome | 205 | |
| chr10:100,744,447–100,746,357 | 215.5 kb | Distal (>10kb) Multiome | 379 | |
| chr10:100,760,518–100,761,080 | 231.0 kb | Distal (>10kb) Multiome | 105 | |
| chr10:100,787,902–100,788,519 | 258.3 kb | Distal (>10kb) Multiome | 52 | |
| chr10:100,826,838–100,828,148 | 298.1 kb | Distal (>10kb) Multiome | 327 |
Genomic view of the NDUFB8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.