A structural constituent of nuclear pore. Involved in nuclear pore complex assembly and nuclear pore localization. Located in actin cytoskeleton; nuclear membrane; and plasma membrane. Part of nuclear pore. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NDC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NDC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NDC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:53,737,700–53,739,665 | 99.2 kb | Distal (>10kb) Multiome | 471 | |
| chr1:53,838,019–53,838,779 | 44 bp | At TSS Multiome | 1058 | |
| chr1:53,889,527–53,890,054 | 51.4 kb | Distal (>10kb) Multiome | 654 | |
| chr1:53,944,886–53,946,958 | 107.5 kb | Distal (>10kb) Multiome | 806 | |
| chr1:53,956,851–53,957,534 | 118.8 kb | Distal (>10kb) Multiome | 255 | |
| chr1:54,052,651–54,054,132 | 215.0 kb | Distal (>10kb) Multiome | 833 | |
| chr1:54,121,133–54,122,207 | 283.2 kb | Distal (>10kb) Multiome | 490 |
Genomic view of the NDC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.