The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]
Transcription factors with Perturb-seq knockdown data for NCOA6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NCOA6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NCOA6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:34,549,322–34,549,906 | 275.9 kb | Distal (>10kb) Multiome | 216 | |
| chr20:34,558,287–34,559,412 | 267.0 kb | Distal (>10kb) Multiome | 380 | |
| chr20:34,676,509–34,677,593 | 148.7 kb | Distal (>10kb) Multiome | 954 | |
| chr20:34,703,810–34,705,103 | 121.1 kb | Distal (>10kb) Multiome | 903 | |
| chr20:34,708,877–34,710,404 | 115.9 kb | Distal (>10kb) Multiome | 576 | |
| chr20:34,824,452–34,825,860 | 204 bp | At TSS Multiome | 852 | |
| chr20:34,872,384–34,873,259 | 47.2 kb | Distal (>10kb) Multiome | 817 | |
| chr20:34,874,110–34,874,535 | 48.7 kb | Distal (>10kb) Multiome | 357 | |
| chr20:34,875,878–34,877,081 | 50.7 kb | Distal (>10kb) Multiome | 852 | |
| chr20:34,955,039–34,956,224 | 130.2 kb | Distal (>10kb) Multiome | 1031 | |
| chr20:34,960,537–34,961,054 | 135.2 kb | Distal (>10kb) Multiome | 275 | |
| chr20:34,979,568–34,980,289 | 154.3 kb | Distal (>10kb) Multiome | 149 | |
| chr20:35,092,320–35,093,398 | 267.2 kb | Distal (>10kb) Multiome | 1139 | |
| chr20:35,262,839–35,263,582 | 437.7 kb | Distal (>10kb) Multiome HiCAR | 336 | |
| chr20:35,269,197–35,269,766 | 443.8 kb | Distal (>10kb) Multiome HiCAR | 447 |
Genomic view of the NCOA6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.