This gene encodes a member of the barr gene family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphase chromatin into condensed chromosomes. The protein encoded by this gene is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During interphase, the protein has a distinct punctate nucleolar localization. Alternatively spliced transcript variants encoding different proteins have been described. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for NCAPH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NCAPH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NCAPH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:96,116,133–96,117,547 | 218.9 kb | Distal (>10kb) Multiome | 470 | |
| chr2:96,138,522–96,139,006 | 197.0 kb | Distal (>10kb) Multiome | 255 | |
| chr2:96,144,225–96,145,701 | 190.5 kb | Distal (>10kb) Multiome | 423 | |
| chr2:96,148,417–96,148,969 | 187.1 kb | Distal (>10kb) Multiome | 318 | |
| chr2:96,207,850–96,209,429 | 126.8 kb | Distal (>10kb) Multiome | 1022 | |
| chr2:96,265,014–96,266,655 | 69.7 kb | Distal (>10kb) Multiome | 992 | |
| chr2:96,305,302–96,305,947 | 30.2 kb | Distal (>10kb) Multiome | 918 | |
| chr2:96,321,245–96,322,149 | 13.9 kb | Distal (>10kb) Multiome | 640 | |
| chr2:96,325,023–96,325,881 | 10.4 kb | Distal (>10kb) Multiome | 443 | |
| chr2:96,335,437–96,336,197 | 156 bp | At TSS Multiome | 847 | |
| chr2:96,507,900–96,508,563 | 172.4 kb | Distal (>10kb) Multiome HiCAR | 466 | |
| chr2:96,509,253–96,509,998 | 173.9 kb | Distal (>10kb) Multiome HiCAR | 525 | |
| chr2:96,531,989–96,532,491 | 196.5 kb | Distal (>10kb) Multiome | 500 | |
| chr2:96,536,180–96,538,128 | 200.9 kb | Distal (>10kb) Multiome | 684 | |
| chr2:96,538,413–96,539,012 | 203.0 kb | Distal (>10kb) Multiome | 371 | |
| chr2:96,554,285–96,554,861 | 218.8 kb | Distal (>10kb) Multiome | 435 |
Genomic view of the NCAPH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.