Enables histone binding activity. Involved in mitotic chromosome condensation and positive regulation of chromosome condensation. Located in several cellular components, including condensed chromosome; microtubule organizing center; and nuclear lumen. Part of condensin complex. Implicated in primary autosomal recessive microcephaly 21. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NCAPD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NCAPD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NCAPD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:6,199,391–6,201,130 | 293.8 kb | Distal (>10kb) Multiome | 481 | |
| chr12:6,214,773–6,215,509 | 278.8 kb | Distal (>10kb) Multiome | 158 | |
| chr12:6,278,466–6,279,375 | 215.3 kb | Distal (>10kb) Multiome | 655 | |
| chr12:6,310,091–6,311,512 | 183.4 kb | Distal (>10kb) Multiome | 645 | |
| chr12:6,322,926–6,323,961 | 170.7 kb | Distal (>10kb) Multiome | 536 | |
| chr12:6,329,238–6,330,028 | 164.6 kb | Distal (>10kb) Multiome | 135 | |
| chr12:6,335,766–6,337,493 | 157.5 kb | Distal (>10kb) Multiome | 962 | |
| chr12:6,341,619–6,342,234 | 151.9 kb | Distal (>10kb) Multiome | 657 | |
| chr12:6,363,292–6,364,138 | 130.5 kb | Distal (>10kb) Multiome | 718 | |
| chr12:6,370,899–6,371,535 | 122.8 kb | Distal (>10kb) Multiome | 572 | |
| chr12:6,375,204–6,377,302 | 118.6 kb | Distal (>10kb) Multiome | 601 | |
| chr12:6,383,790–6,384,442 | 110.0 kb | Distal (>10kb) Multiome | 812 | |
| chr12:6,451,305–6,451,838 | 42.7 kb | Distal (>10kb) Multiome | 535 | |
| chr12:6,469,922–6,471,399 | 23.2 kb | Distal (>10kb) Multiome HiCAR | 930 | |
| chr12:6,492,998–6,494,331 | 782 bp | At TSS Multiome | 936 | |
| chr12:6,533,253–6,535,726 | 40.2 kb | Distal (>10kb) Multiome HiCAR | 1131 | |
| chr12:6,539,914–6,540,883 | 46.6 kb | Distal (>10kb) Multiome | 427 | |
| chr12:6,554,111–6,554,621 | 60.2 kb | Distal (>10kb) Multiome | 407 | |
| chr12:6,555,532–6,556,318 | 62.0 kb | Distal (>10kb) Multiome | 551 | |
| chr12:6,567,822–6,568,719 | 74.3 kb | Distal (>10kb) Multiome | 837 | |
| chr12:6,605,947–6,607,790 | 113.4 kb | Distal (>10kb) Multiome | 774 | |
| chr12:6,613,155–6,614,551 | 120.0 kb | Distal (>10kb) Multiome | 810 | |
| chr12:6,620,128–6,620,868 | 126.4 kb | Distal (>10kb) Multiome | 239 | |
| chr12:6,662,802–6,663,663 | 169.1 kb | Distal (>10kb) Multiome | 868 | |
| chr12:6,688,517–6,690,027 | 195.4 kb | Distal (>10kb) Multiome | 943 | |
| chr12:6,699,959–6,700,887 | 206.4 kb | Distal (>10kb) Multiome | 263 | |
| chr12:6,723,658–6,724,773 | 230.0 kb | Distal (>10kb) Multiome | 1065 | |
| chr12:6,752,554–6,754,332 | 259.4 kb | Distal (>10kb) Multiome | 975 | |
| chr12:6,763,677–6,764,983 | 270.3 kb | Distal (>10kb) Multiome | 570 | |
| chr12:6,765,172–6,767,791 | 272.2 kb | Distal (>10kb) Multiome | 824 | |
| chr12:6,768,329–6,769,331 | 275.0 kb | Distal (>10kb) Multiome | 249 | |
| chr12:6,778,736–6,779,459 | 285.0 kb | Distal (>10kb) Multiome | 777 |
Genomic view of the NCAPD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.