The protein encoded by this gene is an RNA cytidine acetyltransferase involved in histone acetylation, tRNA acetylation, the biosynthesis of 18S rRNA, and the enhancement of nuclear architecture and chromatin organization. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for NAT10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NAT10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NAT10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:33,829,198–33,829,839 | 276.1 kb | Distal (>10kb) Multiome | 203 | |
| chr11:33,868,762–33,870,240 | 235.9 kb | Distal (>10kb) Multiome | 416 | |
| chr11:34,051,095–34,052,918 | 54.0 kb | Distal (>10kb) Multiome | 940 | |
| chr11:34,104,945–34,106,393 | 32 bp | At TSS Multiome | 1046 | |
| chr11:34,174,182–34,174,889 | 68.9 kb | Distal (>10kb) Multiome | 634 | |
| chr11:34,236,421–34,237,093 | 131.2 kb | Distal (>10kb) Multiome | 194 | |
| chr11:34,262,742–34,263,988 | 157.9 kb | Distal (>10kb) Multiome | 426 | |
| chr11:34,302,438–34,303,315 | 197.3 kb | Distal (>10kb) Multiome | 271 | |
| chr11:34,309,995–34,310,608 | 204.7 kb | Distal (>10kb) Multiome | 187 | |
| chr11:34,356,485–34,359,534 | 252.5 kb | Distal (>10kb) Multiome HiCAR | 985 |
Genomic view of the NAT10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.