This gene encodes a member of the soluble N-ethyl-maleimide-sensitive fusion attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. This gene encodes the SNAP beta isoform which has been shown to be preferentially expressed in brain tissue. The encoded protein also interacts with the GluR2 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit C-terminus and may play a role as a chaperone in the molecular processing of the AMPA receptor. [provided by RefSeq, Mar 2017]
Transcription factors with Perturb-seq knockdown data for NAPB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NAPB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NAPB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:23,178,656–23,179,482 | 242.4 kb | Distal (>10kb) Multiome | 198 | |
| chr20:23,211,541–23,212,970 | 209.1 kb | Distal (>10kb) Multiome | 321 | |
| chr20:23,349,714–23,351,638 | 70.8 kb | Distal (>10kb) Multiome | 1037 | |
| chr20:23,357,172–23,358,689 | 63.2 kb | Distal (>10kb) Multiome | 873 | |
| chr20:23,361,395–23,363,116 | 59.4 kb | Distal (>10kb) Multiome | 1092 | |
| chr20:23,420,902–23,421,923 | 121 bp | At TSS Multiome | 823 | |
| chr20:23,637,267–23,638,378 | 216.5 kb | Distal (>10kb) Multiome | 884 |
Genomic view of the NAPB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.