Predicted to act upstream of or within response to bacterium. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NAALADL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NAALADL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NAALADL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:174,231,532–174,233,398 | 208.3 kb | Distal (>10kb) Multiome | 297 | |
| chr3:174,438,487–174,439,252 | 1.7 kb | Proximal (<10kb) | 112 | |
| chr3:174,439,591–174,440,588 | 393 bp | At TSS | 411 | |
| chr3:174,440,738–174,441,965 | 228 bp | At TSS Multiome | 738 | |
| chr3:174,442,085–174,442,265 | 1.1 kb | Proximal (<10kb) | 45 | |
| chr3:174,539,973–174,541,103 | 99.5 kb | Distal (>10kb) Multiome | 256 |
Genomic view of the NAALADL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.