Enables histone H4 acetyltransferase activity and protein-N-terminal amino-acid acetyltransferase activity. Involved in N-terminal protein amino acid acetylation; establishment of mitotic sister chromatid cohesion; and mitotic sister chromatid cohesion, centromeric. Located in cytosol and nucleolus. Part of NatA complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NAA50. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NAA50 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NAA50, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:113,514,383–113,515,648 | 231.1 kb | Distal (>10kb) Multiome | 705 | |
| chr3:113,532,401–113,533,734 | 213.1 kb | Distal (>10kb) Multiome | 388 | |
| chr3:113,695,756–113,697,740 | 49.5 kb | Distal (>10kb) Multiome | 796 | |
| chr3:113,736,609–113,736,802 | 9.4 kb | Proximal (<10kb) | 156 | |
| chr3:113,744,989–113,747,921 | 1.0 kb | Proximal (<10kb) Multiome | 1061 | |
| chr3:113,838,330–113,839,358 | 92.6 kb | Distal (>10kb) Multiome | 588 | |
| chr3:113,947,254–113,948,963 | 201.6 kb | Distal (>10kb) Multiome | 685 |
Genomic view of the NAA50 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.