Predicted to enable transferase activity. Involved in negative regulation of apoptotic process. Located in cytosol; nucleoplasm; and plasma membrane. Part of NatC complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NAA35. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NAA35 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NAA35, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:85,723,025–85,723,722 | 217.8 kb | Distal (>10kb) Multiome | 240 | |
| chr9:85,740,973–85,742,760 | 199.1 kb | Distal (>10kb) Multiome | 834 | |
| chr9:85,804,917–85,805,981 | 135.9 kb | Distal (>10kb) Multiome | 304 | |
| chr9:85,940,728–85,942,035 | 107 bp | At TSS Multiome | 889 | |
| chr9:86,098,791–86,100,295 | 158.3 kb | Distal (>10kb) Multiome | 436 | |
| chr9:86,118,248–86,119,118 | 177.4 kb | Distal (>10kb) Multiome | 10 | |
| chr9:86,126,993–86,127,913 | 186.3 kb | Distal (>10kb) Multiome | 439 | |
| chr9:86,186,986–86,187,492 | 246.1 kb | Distal (>10kb) Multiome | 90 |
Genomic view of the NAA35 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.