Predicted to enable hydrolase activity, hydrolyzing O-glycosyl compounds. Involved in skeletal muscle fiber development. Predicted to be located in endoplasmic reticulum membrane and nuclear membrane. Implicated in basal ganglia calcification. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MYORG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYORG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYORG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:34,126,146–34,127,302 | 250.2 kb | Distal (>10kb) Multiome | 826 | |
| chr9:34,178,460–34,179,845 | 197.8 kb | Distal (>10kb) Multiome | 814 | |
| chr9:34,328,711–34,329,961 | 47.5 kb | Distal (>10kb) Multiome | 768 | |
| chr9:34,363,597–34,364,212 | 13.0 kb | Distal (>10kb) Multiome | 104 | |
| chr9:34,372,619–34,372,889 | 4.0 kb | Proximal (<10kb) | 88 | |
| chr9:34,374,953–34,375,681 | 1.7 kb | Proximal (<10kb) Multiome | 432 | |
| chr9:34,376,008–34,377,655 | 139 bp | At TSS Multiome | 779 | |
| chr9:34,379,248–34,381,674 | 4.0 kb | Proximal (<10kb) Multiome | 763 | |
| chr9:34,456,881–34,459,235 | 81.8 kb | Distal (>10kb) Multiome | 704 | |
| chr9:34,522,211–34,523,972 | 146.3 kb | Distal (>10kb) Multiome | 473 | |
| chr9:34,589,298–34,591,068 | 212.9 kb | Distal (>10kb) Multiome | 258 | |
| chr9:34,591,283–34,592,013 | 214.9 kb | Distal (>10kb) Multiome | 368 | |
| chr9:34,611,663–34,612,738 | 235.3 kb | Distal (>10kb) Multiome | 680 | |
| chr9:34,620,108–34,620,704 | 243.6 kb | Distal (>10kb) Multiome | 467 | |
| chr9:34,637,123–34,638,475 | 261.0 kb | Distal (>10kb) Multiome | 872 | |
| chr9:34,646,247–34,647,338 | 269.8 kb | Distal (>10kb) Multiome | 857 | |
| chr9:34,651,771–34,652,431 | 275.2 kb | Distal (>10kb) Multiome | 669 | |
| chr9:34,664,346–34,666,446 | 288.7 kb | Distal (>10kb) Multiome | 707 | |
| chr9:34,674,895–34,675,574 | 298.3 kb | Distal (>10kb) Multiome | 372 |
Genomic view of the MYORG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.