This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for MYO6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYO6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYO6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:75,601,534–75,603,064 | 147.3 kb | Distal (>10kb) Multiome | 930 | |
| chr6:75,748,550–75,749,954 | 89 bp | At TSS Multiome | 752 | |
| chr6:75,750,076–75,750,268 | 842 bp | At TSS | 20 | |
| chr6:75,893,205–75,893,597 | 3.0 kb | Proximal (<10kb) | 149 | |
| chr6:76,119,812–76,120,903 | 371.2 kb | Distal (>10kb) Multiome | 241 | |
| chr6:77,461,969–77,464,815 | 1715.1 kb | Distal (>10kb) Multiome HiCAR | 430 |
Genomic view of the MYO6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.