Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MYO5C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYO5C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYO5C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:52,008,542–52,009,373 | 286.8 kb | Distal (>10kb) Multiome | 499 | |
| chr15:52,018,740–52,020,253 | 276.5 kb | Distal (>10kb) Multiome | 1045 | |
| chr15:52,111,990–52,112,768 | 183.4 kb | Distal (>10kb) Multiome | 189 | |
| chr15:52,139,658–52,140,475 | 155.8 kb | Distal (>10kb) Multiome | 400 | |
| chr15:52,179,295–52,180,708 | 116.0 kb | Distal (>10kb) Multiome | 715 | |
| chr15:52,261,434–52,262,154 | 33.9 kb | Distal (>10kb) Multiome | 313 | |
| chr15:52,294,913–52,296,036 | 13 bp | At TSS Multiome | 630 | |
| chr15:52,392,159–52,392,836 | 96.7 kb | Distal (>10kb) Multiome | 167 | |
| chr15:52,528,126–52,529,827 | 233.2 kb | Distal (>10kb) Multiome | 619 | |
| chr15:52,568,541–52,569,521 | 273.3 kb | Distal (>10kb) Multiome | 996 |
Genomic view of the MYO5C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.