Myosins are molecular motors that use the energy from ATP hydrolysis to generate force on actin filaments. The protein encoded by this gene is an unconventional myosin that may be involved in the intracellular movement of membrane-enclosed compartments. There is evidence to suggest that mutations in this gene can result in hearing loss. [provided by RefSeq, Jan 2017]
Transcription factors with Perturb-seq knockdown data for MYO1F. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYO1F upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYO1F, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:8,307,739–8,308,717 | 269.2 kb | Distal (>10kb) Multiome | 973 | |
| chr19:8,314,738–8,315,490 | 262.4 kb | Distal (>10kb) Multiome | 49 | |
| chr19:8,320,824–8,321,811 | 256.0 kb | Distal (>10kb) Multiome | 871 | |
| chr19:8,334,500–8,335,843 | 242.1 kb | Distal (>10kb) Multiome | 384 | |
| chr19:8,342,762–8,343,678 | 234.1 kb | Distal (>10kb) Multiome | 440 | |
| chr19:8,363,586–8,364,765 | 213.4 kb | Distal (>10kb) Multiome | 549 | |
| chr19:8,389,684–8,391,548 | 187.2 kb | Distal (>10kb) Multiome | 878 | |
| chr19:8,412,769–8,413,775 | 164.3 kb | Distal (>10kb) Multiome | 566 | |
| chr19:8,444,605–8,445,806 | 132.6 kb | Distal (>10kb) Multiome | 910 | |
| chr19:8,505,742–8,506,861 | 71.2 kb | Distal (>10kb) Multiome | 739 | |
| chr19:8,511,414–8,512,588 | 65.4 kb | Distal (>10kb) Multiome | 263 | |
| chr19:8,513,025–8,514,530 | 63.5 kb | Distal (>10kb) Multiome | 825 | |
| chr19:8,525,196–8,527,085 | 51.7 kb | Distal (>10kb) Multiome | 783 | |
| chr19:8,578,815–8,578,982 | 1.4 kb | Proximal (<10kb) | 224 | |
| chr19:8,580,484–8,581,056 | 3.5 kb | Proximal (<10kb) Multiome | 535 | |
| chr19:8,586,013–8,586,248 | 8.6 kb | Proximal (<10kb) | 232 | |
| chr19:8,591,781–8,593,224 | 15.0 kb | Distal (>10kb) Multiome | 389 | |
| chr19:8,609,061–8,609,913 | 32.1 kb | Distal (>10kb) Multiome | 432 | |
| chr19:8,832,015–8,833,117 | 255.3 kb | Distal (>10kb) Multiome | 694 | |
| chr19:9,818,302–9,820,113 | 1241.9 kb | Distal (>10kb) Multiome HiCAR | 870 |
Genomic view of the MYO1F locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.