Predicted to enable ATP binding activity; actin binding activity; and cytoskeletal motor activity. Predicted to be located in brush border; cytoplasm; and cytoskeleton. Predicted to be part of myosin complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MYO15B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYO15B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYO15B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:75,288,761–75,289,874 | 298.5 kb | Distal (>10kb) Multiome | 941 | |
| chr17:75,346,809–75,347,324 | 240.9 kb | Distal (>10kb) Multiome | 265 | |
| chr17:75,393,479–75,394,300 | 194.1 kb | Distal (>10kb) Multiome | 834 | |
| chr17:75,404,856–75,406,161 | 182.3 kb | Distal (>10kb) Multiome | 917 | |
| chr17:75,456,149–75,457,264 | 131.5 kb | Distal (>10kb) Multiome | 865 | |
| chr17:75,481,081–75,481,680 | 106.7 kb | Distal (>10kb) Multiome | 64 | |
| chr17:75,514,425–75,517,171 | 72.4 kb | Distal (>10kb) Multiome HiCAR | 1158 | |
| chr17:75,524,764–75,527,160 | 62.5 kb | Distal (>10kb) Multiome | 951 | |
| chr17:75,549,465–75,550,388 | 38.1 kb | Distal (>10kb) Multiome | 602 | |
| chr17:75,587,697–75,590,735 | 1.3 kb | Proximal (<10kb) Multiome | 744 | |
| chr17:75,633,694–75,634,328 | 46.0 kb | Distal (>10kb) Multiome | 559 | |
| chr17:75,666,763–75,667,767 | 79.2 kb | Distal (>10kb) Multiome | 783 | |
| chr17:75,720,933–75,721,693 | 133.3 kb | Distal (>10kb) Multiome | 509 | |
| chr17:75,753,534–75,754,285 | 165.8 kb | Distal (>10kb) Multiome | 699 | |
| chr17:75,764,621–75,765,674 | 177.1 kb | Distal (>10kb) Multiome | 769 | |
| chr17:75,778,786–75,780,191 | 191.8 kb | Distal (>10kb) Multiome | 1118 | |
| chr17:75,784,060–75,785,640 | 196.8 kb | Distal (>10kb) Multiome | 1176 | |
| chr17:75,827,420–75,828,293 | 239.8 kb | Distal (>10kb) Multiome | 404 | |
| chr17:75,830,158–75,830,695 | 242.3 kb | Distal (>10kb) Multiome | 190 | |
| chr17:75,832,912–75,833,396 | 245.1 kb | Distal (>10kb) Multiome | 104 | |
| chr17:75,845,103–75,845,662 | 257.3 kb | Distal (>10kb) Multiome | 703 | |
| chr17:75,854,955–75,856,363 | 267.5 kb | Distal (>10kb) Multiome | 1038 | |
| chr17:75,877,486–75,878,900 | 290.0 kb | Distal (>10kb) Multiome | 884 |
Genomic view of the MYO15B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.