The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for MVB12B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MVB12B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MVB12B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:125,407,852–125,408,856 | 918.6 kb | Distal (>10kb) Multiome HiCAR | 615 | |
| chr9:126,326,281–126,327,488 | 51 bp | At TSS Multiome | 391 | |
| chr9:126,499,263–126,500,429 | 172.7 kb | Distal (>10kb) Multiome | 380 | |
| chr9:126,500,475–126,501,408 | 174.3 kb | Distal (>10kb) Multiome | 410 | |
| chr9:126,513,839–126,514,723 | 187.5 kb | Distal (>10kb) Multiome | 300 | |
| chr9:126,558,118–126,558,952 | 231.6 kb | Distal (>10kb) Multiome | 249 | |
| chr9:126,563,772–126,564,725 | 237.5 kb | Distal (>10kb) Multiome | 196 | |
| chr9:126,611,172–126,613,546 | 284.9 kb | Distal (>10kb) Multiome | 435 | |
| chr9:126,613,728–126,614,227 | 287.1 kb | Distal (>10kb) Multiome | 310 |
Genomic view of the MVB12B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.