This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]
Transcription factors with Perturb-seq knockdown data for MUTYH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MUTYH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MUTYH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:45,010,856–45,013,180 | 328.2 kb | Distal (>10kb) Multiome HiCAR | 909 | |
| chr1:45,205,664–45,207,097 | 133.9 kb | Distal (>10kb) Multiome | 691 | |
| chr1:45,216,712–45,217,234 | 123.4 kb | Distal (>10kb) Multiome | 42 | |
| chr1:45,303,203–45,304,881 | 36.6 kb | Distal (>10kb) Multiome | 1034 | |
| chr1:45,315,837–45,316,870 | 24.3 kb | Distal (>10kb) Multiome | 113 | |
| chr1:45,317,165–45,317,643 | 23.0 kb | Distal (>10kb) Multiome | 7 | |
| chr1:45,321,623–45,322,180 | 18.7 kb | Distal (>10kb) Multiome | 54 | |
| chr1:45,326,327–45,328,092 | 13.5 kb | Distal (>10kb) Multiome | 382 | |
| chr1:45,339,505–45,340,694 | 288 bp | At TSS Multiome | 951 | |
| chr1:45,490,605–45,491,773 | 150.9 kb | Distal (>10kb) Multiome HiCAR | 900 | |
| chr1:45,499,499–45,500,620 | 159.7 kb | Distal (>10kb) Multiome HiCAR | 831 | |
| chr1:45,521,163–45,522,604 | 181.6 kb | Distal (>10kb) Multiome | 1155 | |
| chr1:45,550,427–45,551,304 | 210.4 kb | Distal (>10kb) Multiome | 1006 | |
| chr1:45,583,145–45,585,182 | 244.3 kb | Distal (>10kb) Multiome | 997 | |
| chr1:45,622,461–45,623,374 | 282.6 kb | Distal (>10kb) Multiome | 169 |
Genomic view of the MUTYH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.