Predicted to be involved in mitochondrion organization. Located in mitochondrion. Part of MIB complex and SAM complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MTX3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTX3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTX3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:79,990,706–79,991,420 | 68 bp | At TSS Multiome | 773 | |
| chr5:80,034,875–80,035,788 | 44.2 kb | Distal (>10kb) Multiome | 189 | |
| chr5:80,093,737–80,094,335 | 102.9 kb | Distal (>10kb) Multiome | 220 | |
| chr5:80,111,066–80,112,197 | 120.3 kb | Distal (>10kb) Multiome | 104 | |
| chr5:80,141,245–80,141,718 | 150.3 kb | Distal (>10kb) Multiome | 179 | |
| chr5:80,180,501–80,181,544 | 189.8 kb | Distal (>10kb) Multiome | 195 | |
| chr5:80,183,069–80,185,467 | 192.2 kb | Distal (>10kb) Multiome | 646 | |
| chr5:80,185,568–80,186,143 | 194.5 kb | Distal (>10kb) Multiome | 70 | |
| chr5:80,204,750–80,205,627 | 213.8 kb | Distal (>10kb) Multiome | 594 | |
| chr5:80,255,259–80,256,736 | 264.8 kb | Distal (>10kb) Multiome | 873 | |
| chr5:80,257,220–80,257,979 | 266.5 kb | Distal (>10kb) Multiome | 496 |
Genomic view of the MTX3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.