The protein encoded by this gene was determined by in silico methods to be a mitochondrial protein with similarity to the peptide chain release factors (RFs) discovered in bacteria and yeast. The peptide chain release factors direct the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis, a recent publication found no mitochondrial translation release functionality. Multiple alternatively spliced transcript variants have been suggested by mRNA and EST data; however, their full-length natures are not clear. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MTRF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTRF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTRF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:41,060,003–41,062,196 | 201.9 kb | Distal (>10kb) Multiome | 1139 | |
| chr13:41,085,849–41,086,392 | 177.5 kb | Distal (>10kb) Multiome | 126 | |
| chr13:41,107,127–41,108,367 | 155.8 kb | Distal (>10kb) Multiome | 291 | |
| chr13:41,132,141–41,133,085 | 130.8 kb | Distal (>10kb) Multiome | 774 | |
| chr13:41,194,020–41,194,940 | 69.1 kb | Distal (>10kb) Multiome | 837 | |
| chr13:41,263,241–41,263,968 | 86 bp | At TSS Multiome | 597 | |
| chr13:41,310,956–41,312,145 | 47.7 kb | Distal (>10kb) Multiome | 855 | |
| chr13:41,456,776–41,458,736 | 193.8 kb | Distal (>10kb) Multiome | 626 |
Genomic view of the MTRF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.