Enables ribosomal large subunit binding activity and tRNA binding activity. Involved in regulation of mitochondrial transcription and rescue of stalled ribosome. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MTRES1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTRES1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTRES1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:106,973,315–106,975,918 | 53.2 kb | Distal (>10kb) Multiome | 630 | |
| chr6:107,027,839–107,028,798 | 39 bp | At TSS Multiome | 935 | |
| chr6:107,061,167–107,063,474 | 33.4 kb | Distal (>10kb) Multiome | 251 | |
| chr6:107,114,151–107,117,016 | 86.3 kb | Distal (>10kb) Multiome | 998 | |
| chr6:107,138,690–107,139,329 | 110.9 kb | Distal (>10kb) Multiome | 83 |
Genomic view of the MTRES1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.