MTIF3

mitochondrial translational initiation factor 3 | IF-3mt, IF3(mt)

This gene encodes a translation initiation factor that is involved in mitochondrial protein synthesis. Polymorphism in this gene is associated with the onset of Parkinson's disease. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Oct 2009]

Member of: DE-7 Developmental clusters: GC5

Biological processes 13 terms

mitochondrial translational initiation (GO:0070124)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)protein binding (GO:0005515)ribosomal small subunit binding (GO:0043024)ribosome disassembly (GO:0032790)ribosome disassembly (GO:0032790)translation factor activity, RNA binding (GO:0008135)translation initiation factor activity (GO:0003743)translation initiation factor activity (GO:0003743)translational initiation (GO:0006413)

Expression (TPM)

TFs regulating MTIF3 0 TFs

Transcription factors with Perturb-seq knockdown data for MTIF3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTIF3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MTIF3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTIF3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr13:27,170,635–27,172,412	278.6 kb	Distal (>10kb) Multiome	737
chr13:27,251,189–27,251,961	199.1 kb	Distal (>10kb) Multiome	890
chr13:27,270,323–27,271,477	179.7 kb	Distal (>10kb) Multiome	687
chr13:27,361,835–27,362,747	88.4 kb	Distal (>10kb) Multiome	476
chr13:27,424,036–27,425,195	26.0 kb	Distal (>10kb) Multiome	868
chr13:27,449,915–27,451,120	273 bp	At TSS Multiome	928
chr13:27,619,862–27,622,369	171.3 kb	Distal (>10kb) Multiome	1017
chr13:27,792,386–27,793,032	342.0 kb	Distal (>10kb) Multiome HiCAR	381
chr13:27,826,355–27,826,879	376.1 kb	Distal (>10kb) Multiome HiCAR	341

Genome Browser

Genomic view of the MTIF3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.