MTHFD2L

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like | MGC72244

Predicted to enable methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NAD+) activity; and methylenetetrahydrofolate dehydrogenase (NADP+) activity. Predicted to be involved in tetrahydrofolate interconversion. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-7 DE-7.2 Developmental clusters: GC5

Biological processes 22 terms

catalytic activity (GO:0003824)folic acid metabolic process (GO:0046655)folic acid metabolic process (GO:0046655)methenyltetrahydrofolate cyclohydrolase activity (GO:0004477)methenyltetrahydrofolate cyclohydrolase activity (GO:0004477)methenyltetrahydrofolate cyclohydrolase activity (GO:0004477)methenyltetrahydrofolate cyclohydrolase activity (GO:0004477)methylenetetrahydrofolate dehydrogenase (NAD+) activity (GO:0004487)methylenetetrahydrofolate dehydrogenase (NAD+) activity (GO:0004487)methylenetetrahydrofolate dehydrogenase (NAD+) activity (GO:0004487)methylenetetrahydrofolate dehydrogenase (NADP+) activity (GO:0004488)methylenetetrahydrofolate dehydrogenase (NADP+) activity (GO:0004488)methylenetetrahydrofolate dehydrogenase (NADP+) activity (GO:0004488)mitochondrial inner membrane (GO:0005743)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrion (GO:0005739)mitochondrion (GO:0005739)protein binding (GO:0005515)tetrahydrofolate interconversion (GO:0035999)tetrahydrofolate interconversion (GO:0035999)tetrahydrofolate interconversion (GO:0035999)

Expression (TPM)

TFs regulating MTHFD2L 0 TFs

Transcription factors with Perturb-seq knockdown data for MTHFD2L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTHFD2L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MTHFD2L

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTHFD2L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr4:73,868,810–73,870,004	288.8 kb	Distal (>10kb) Multiome	324
chr4:73,964,757–73,965,610	193.0 kb	Distal (>10kb) Multiome	149
chr4:73,984,904–73,985,864	172.8 kb	Distal (>10kb) Multiome	216
chr4:73,997,921–73,999,060	159.5 kb	Distal (>10kb) Multiome	310
chr4:74,038,092–74,039,696	119.4 kb	Distal (>10kb) Multiome	491
chr4:74,098,624–74,099,683	59.0 kb	Distal (>10kb) Multiome	642
chr4:74,157,425–74,158,601	138 bp	At TSS Multiome	916
chr4:74,364,613–74,365,589	207.1 kb	Distal (>10kb) Multiome	421
chr4:74,444,835–74,445,871	287.2 kb	Distal (>10kb) Multiome	594

Genome Browser

Genomic view of the MTHFD2L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.