Enables microtubule binding activity. Involved in chromosome segregation. Located in kinetochore; midbody; and spindle. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MTCL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTCL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTCL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:8,608,780–8,609,797 | 96.3 kb | Distal (>10kb) Multiome | 603 | |
| chr18:8,622,344–8,623,165 | 82.8 kb | Distal (>10kb) Multiome | 162 | |
| chr18:8,661,718–8,663,453 | 43.0 kb | Distal (>10kb) Multiome | 369 | |
| chr18:8,696,847–8,697,020 | 8.5 kb | Proximal (<10kb) | 196 | |
| chr18:8,704,354–8,706,945 | 372 bp | At TSS Multiome | 610 | |
| chr18:8,707,025–8,707,559 | 1.8 kb | Proximal (<10kb) Multiome | 299 | |
| chr18:8,717,390–8,717,753 | 20 bp | At TSS | 78 | |
| chr18:8,937,255–8,938,296 | 232.2 kb | Distal (>10kb) Multiome | 208 |
Genomic view of the MTCL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.