Sterol-C4-mehtyl oxidase-like protein was isolated based on its similarity to the yeast ERG25 protein. It contains a set of putative metal binding motifs with similarity to that seen in a family of membrane desaturases-hydroxylases. The protein is localized to the endoplasmic reticulum membrane and is believed to function in cholesterol biosynthesis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MSMO1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MSMO1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MSMO1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:165,073,162–165,074,288 | 254.2 kb | Distal (>10kb) Multiome | 65 | |
| chr4:165,112,149–165,113,934 | 214.9 kb | Distal (>10kb) Multiome HiCAR | 902 | |
| chr4:165,206,424–165,208,519 | 120.1 kb | Distal (>10kb) Multiome HiCAR | 645 | |
| chr4:165,325,708–165,326,145 | 1.6 kb | Proximal (<10kb) | 261 | |
| chr4:165,326,454–165,328,403 | 186 bp | At TSS Multiome | 919 | |
| chr4:165,330,761–165,331,103 | 3.0 kb | Proximal (<10kb) | 41 | |
| chr4:165,331,460–165,331,622 | 3.7 kb | Proximal (<10kb) | 33 | |
| chr4:165,331,909–165,332,119 | 4.2 kb | Proximal (<10kb) | 61 | |
| chr4:165,378,748–165,380,262 | 51.4 kb | Distal (>10kb) Multiome | 796 | |
| chr4:165,383,752–165,384,923 | 56.6 kb | Distal (>10kb) Multiome | 263 | |
| chr4:165,493,149–165,493,950 | 165.8 kb | Distal (>10kb) Multiome | 270 |
Genomic view of the MSMO1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.