Enables histone H2B ubiquitin ligase activity. Involved in DNA damage response and protein monoubiquitination. Located in nucleus. Part of MSL complex. Is active in chromatin. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MSL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MSL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MSL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:135,964,966–135,966,640 | 230.8 kb | Distal (>10kb) Multiome | 613 | |
| chr3:136,190,868–136,191,253 | 5.1 kb | Proximal (<10kb) | 44 | |
| chr3:136,195,015–136,197,281 | 30 bp | At TSS Multiome | 1181 | |
| chr3:136,250,052–136,250,960 | 53.9 kb | Distal (>10kb) Multiome | 921 | |
| chr3:136,277,708–136,278,186 | 81.3 kb | Distal (>10kb) Multiome | 166 |
Genomic view of the MSL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.