Transcription factors with Perturb-seq knockdown data for MSANTD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MSANTD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MSANTD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:124,622,373–124,623,302 | 153.4 kb | Distal (>10kb) Multiome | 828 | |
| chr11:124,673,250–124,674,391 | 102.4 kb | Distal (>10kb) Multiome | 715 | |
| chr11:124,739,482–124,740,822 | 36.3 kb | Distal (>10kb) Multiome | 498 | |
| chr11:124,745,504–124,747,699 | 29.3 kb | Distal (>10kb) Multiome | 676 | |
| chr11:124,758,225–124,760,203 | 17.7 kb | Distal (>10kb) Multiome | 594 | |
| chr11:124,799,320–124,800,957 | 24.3 kb | Distal (>10kb) Multiome | 893 | |
| chr11:124,839,093–124,840,110 | 63.5 kb | Distal (>10kb) Multiome | 246 | |
| chr11:124,842,870–124,844,108 | 67.1 kb | Distal (>10kb) Multiome | 219 | |
| chr11:124,875,886–124,877,815 | 100.3 kb | Distal (>10kb) Multiome | 769 | |
| chr11:124,920,725–124,921,671 | 144.9 kb | Distal (>10kb) Multiome | 329 | |
| chr11:124,953,809–124,954,493 | 177.8 kb | Distal (>10kb) Multiome | 818 | |
| chr11:125,062,600–125,064,019 | 287.0 kb | Distal (>10kb) Multiome | 640 |
Genomic view of the MSANTD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.