This gene encodes a protein sharing a low level of sequence similarity with ribosomal protein P0. While the precise function of the encoded protein is currently unknown, it appears to be involved in mRNA turnover and ribosome assembly. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MRTO4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRTO4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRTO4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:18,955,480–18,957,564 | 295.0 kb | Distal (>10kb) Multiome | 702 | |
| chr1:19,209,669–19,210,758 | 41.5 kb | Distal (>10kb) Multiome | 990 | |
| chr1:19,251,426–19,252,084 | 145 bp | At TSS Multiome | 930 | |
| chr1:19,311,493–19,312,976 | 60.4 kb | Distal (>10kb) Multiome | 868 | |
| chr1:19,338,257–19,338,718 | 86.7 kb | Distal (>10kb) Multiome | 426 | |
| chr1:19,484,474–19,486,386 | 233.9 kb | Distal (>10kb) Multiome | 809 | |
| chr1:19,653,578–19,654,269 | 402.2 kb | Distal (>10kb) Multiome HiCAR | 321 | |
| chr1:19,659,723–19,660,209 | 408.2 kb | Distal (>10kb) Multiome HiCAR | 316 |
Genomic view of the MRTO4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.