Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MRPS9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRPS9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRPS9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:103,176,132–103,177,162 | 1861.5 kb | Distal (>10kb) Multiome HiCAR | 106 | |
| chr2:104,758,127–104,758,698 | 279.7 kb | Distal (>10kb) Multiome | 137 | |
| chr2:104,842,362–104,844,111 | 195.0 kb | Distal (>10kb) Multiome | 328 | |
| chr2:104,844,412–104,845,692 | 192.9 kb | Distal (>10kb) Multiome | 270 | |
| chr2:104,852,203–104,854,491 | 184.1 kb | Distal (>10kb) Multiome | 475 | |
| chr2:104,861,633–104,862,667 | 175.7 kb | Distal (>10kb) Multiome | 214 | |
| chr2:104,863,519–104,864,305 | 174.1 kb | Distal (>10kb) Multiome | 122 | |
| chr2:104,872,110–104,874,183 | 164.5 kb | Distal (>10kb) Multiome | 550 | |
| chr2:105,037,323–105,038,877 | 56 bp | At TSS Multiome | 844 | |
| chr2:105,102,893–105,103,524 | 65.0 kb | Distal (>10kb) Multiome | 260 | |
| chr2:105,125,477–105,126,235 | 87.7 kb | Distal (>10kb) Multiome | 89 | |
| chr2:105,139,777–105,140,585 | 102.3 kb | Distal (>10kb) Multiome | 110 | |
| chr2:105,143,409–105,144,624 | 105.9 kb | Distal (>10kb) Multiome | 295 | |
| chr2:105,177,474–105,178,378 | 139.8 kb | Distal (>10kb) Multiome | 179 | |
| chr2:105,237,985–105,238,461 | 200.1 kb | Distal (>10kb) Multiome | 181 | |
| chr2:105,329,281–105,330,301 | 291.7 kb | Distal (>10kb) Multiome | 799 | |
| chr2:105,337,038–105,338,021 | 299.4 kb | Distal (>10kb) Multiome | 812 |
Genomic view of the MRPS9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.