Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. The mitochondrial ribosome (mitoribosome) consists of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 3p, 4q, 8p, 11q, 12q, and 20p. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MRPS36. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRPS36 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRPS36, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:68,922,292–68,922,890 | 295.2 kb | Distal (>10kb) Multiome | 63 | |
| chr5:69,093,377–69,094,772 | 123.8 kb | Distal (>10kb) Multiome | 952 | |
| chr5:69,166,575–69,167,819 | 50.7 kb | Distal (>10kb) Multiome | 840 | |
| chr5:69,188,979–69,190,115 | 28.2 kb | Distal (>10kb) Multiome | 898 | |
| chr5:69,217,542–69,218,587 | 219 bp | At TSS Multiome | 898 | |
| chr5:69,234,302–69,235,305 | 17.1 kb | Distal (>10kb) Multiome | 732 | |
| chr5:69,300,544–69,301,286 | 83.1 kb | Distal (>10kb) Multiome | 217 | |
| chr5:69,368,998–69,370,235 | 151.9 kb | Distal (>10kb) Multiome | 956 | |
| chr5:69,414,852–69,415,897 | 197.4 kb | Distal (>10kb) Multiome | 714 | |
| chr5:69,492,169–69,494,057 | 274.9 kb | Distal (>10kb) Multiome | 821 | |
| chr5:69,499,604–69,500,518 | 282.3 kb | Distal (>10kb) Multiome | 300 |
Genomic view of the MRPS36 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.