Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 11. Read-through transcription exists between this gene and the upstream upregulator of cell proliferation (URGCP) gene. [provided by RefSeq, Mar 2011]
Transcription factors with Perturb-seq knockdown data for MRPS24. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRPS24 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRPS24, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:43,582,521–43,583,972 | 286.5 kb | Distal (>10kb) Multiome | 861 | |
| chr7:43,729,165–43,729,933 | 139.9 kb | Distal (>10kb) Multiome | 896 | |
| chr7:43,758,058–43,759,333 | 110.7 kb | Distal (>10kb) Multiome | 665 | |
| chr7:43,838,582–43,839,204 | 30.5 kb | Distal (>10kb) Multiome | 647 | |
| chr7:43,868,905–43,870,110 | 40 bp | At TSS Multiome | 804 | |
| chr7:43,905,962–43,907,078 | 37.1 kb | Distal (>10kb) Multiome | 557 | |
| chr7:43,926,113–43,927,072 | 57.1 kb | Distal (>10kb) Multiome | 1004 | |
| chr7:43,985,975–43,986,501 | 116.8 kb | Distal (>10kb) Multiome | 113 | |
| chr7:44,018,938–44,019,667 | 149.7 kb | Distal (>10kb) Multiome | 564 | |
| chr7:44,038,952–44,039,494 | 169.7 kb | Distal (>10kb) Multiome | 215 | |
| chr7:44,044,335–44,045,323 | 175.2 kb | Distal (>10kb) Multiome | 832 | |
| chr7:44,063,611–44,064,251 | 194.5 kb | Distal (>10kb) Multiome | 121 | |
| chr7:44,065,163–44,066,086 | 196.4 kb | Distal (>10kb) Multiome | 198 | |
| chr7:44,081,995–44,083,183 | 213.2 kb | Distal (>10kb) Multiome | 909 | |
| chr7:44,103,745–44,105,419 | 234.8 kb | Distal (>10kb) Multiome | 267 | |
| chr7:44,112,627–44,113,466 | 243.5 kb | Distal (>10kb) Multiome | 237 | |
| chr7:44,123,183–44,124,199 | 254.1 kb | Distal (>10kb) Multiome | 814 | |
| chr7:44,145,408–44,146,956 | 276.7 kb | Distal (>10kb) Multiome | 347 |
Genomic view of the MRPS24 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.