Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family members. A pseudogene corresponding to this gene is found on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]
Transcription factors with Perturb-seq knockdown data for MRPS11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRPS11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRPS11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:88,246,462–88,247,390 | 220.7 kb | Distal (>10kb) Multiome | 349 | |
| chr15:88,256,583–88,257,904 | 210.9 kb | Distal (>10kb) Multiome | 199 | |
| chr15:88,258,031–88,258,757 | 209.3 kb | Distal (>10kb) Multiome | 208 | |
| chr15:88,388,191–88,389,364 | 78.9 kb | Distal (>10kb) Multiome | 280 | |
| chr15:88,467,068–88,468,013 | 177 bp | At TSS Multiome | 857 | |
| chr15:88,476,641–88,477,122 | 8.9 kb | Proximal (<10kb) | 212 | |
| chr15:88,477,228–88,477,754 | 9.5 kb | Proximal (<10kb) | 24 | |
| chr15:88,537,723–88,539,073 | 71.0 kb | Distal (>10kb) Multiome | 141 | |
| chr15:88,545,733–88,547,888 | 78.8 kb | Distal (>10kb) Multiome | 818 | |
| chr15:88,571,230–88,572,235 | 104.0 kb | Distal (>10kb) Multiome | 149 | |
| chr15:88,604,930–88,605,917 | 138.0 kb | Distal (>10kb) Multiome | 530 | |
| chr15:88,610,494–88,611,216 | 143.2 kb | Distal (>10kb) Multiome HiCAR | 201 | |
| chr15:88,612,843–88,613,762 | 145.7 kb | Distal (>10kb) Multiome | 214 | |
| chr15:88,614,278–88,615,021 | 147.0 kb | Distal (>10kb) Multiome HiCAR | 414 | |
| chr15:88,620,659–88,621,775 | 153.6 kb | Distal (>10kb) Multiome | 829 | |
| chr15:88,638,306–88,639,588 | 171.2 kb | Distal (>10kb) Multiome | 1000 |
Genomic view of the MRPS11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.