Transcription factors with Perturb-seq knockdown data for MRPL45P2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRPL45P2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRPL45P2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:47,253,593–47,254,400 | 238.5 kb | Distal (>10kb) Multiome | 571 | |
| chr17:47,275,398–47,275,943 | 216.8 kb | Distal (>10kb) Multiome | 340 | |
| chr17:47,310,107–47,310,844 | 182.0 kb | Distal (>10kb) Multiome | 92 | |
| chr17:47,323,422–47,324,660 | 168.5 kb | Distal (>10kb) Multiome | 1009 | |
| chr17:47,423,404–47,423,999 | 68.7 kb | Distal (>10kb) Multiome | 129 | |
| chr17:47,492,389–47,492,834 | at TSS | At TSS | 482 | |
| chr17:47,531,659–47,532,268 | 39.7 kb | Distal (>10kb) Multiome | 159 | |
| chr17:47,648,863–47,650,987 | 157.2 kb | Distal (>10kb) Multiome | 1152 | |
| chr17:47,693,705–47,695,210 | 202.0 kb | Distal (>10kb) Multiome | 619 | |
| chr17:47,733,002–47,733,810 | 240.8 kb | Distal (>10kb) Multiome | 366 | |
| chr17:47,789,633–47,790,336 | 297.6 kb | Distal (>10kb) Multiome | 395 |
Genomic view of the MRPL45P2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.