Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 2p. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MRPL36. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRPL36 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRPL36, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:1,523,066–1,524,710 | 275.7 kb | Distal (>10kb) Multiome | 630 | |
| chr5:1,593,846–1,595,021 | 205.3 kb | Distal (>10kb) Multiome | 682 | |
| chr5:1,633,700–1,634,325 | 165.8 kb | Distal (>10kb) Multiome | 745 | |
| chr5:1,644,948–1,645,570 | 154.7 kb | Distal (>10kb) Multiome | 437 | |
| chr5:1,666,897–1,668,526 | 132.5 kb | Distal (>10kb) Multiome | 301 | |
| chr5:1,799,167–1,800,245 | 11 bp | At TSS Multiome | 744 | |
| chr5:1,800,343–1,801,861 | 1.6 kb | Proximal (<10kb) Multiome | 895 | |
| chr5:1,801,960–1,802,143 | 2.1 kb | Proximal (<10kb) | 100 | |
| chr5:1,827,805–1,828,459 | 28.3 kb | Distal (>10kb) Multiome | 84 | |
| chr5:1,867,435–1,868,302 | 67.8 kb | Distal (>10kb) Multiome | 169 | |
| chr5:1,874,486–1,877,084 | 75.1 kb | Distal (>10kb) Multiome | 194 | |
| chr5:1,880,966–1,883,137 | 82.8 kb | Distal (>10kb) Multiome | 459 | |
| chr5:1,883,292–1,884,343 | 84.0 kb | Distal (>10kb) Multiome | 279 | |
| chr5:1,884,792–1,888,153 | 87.4 kb | Distal (>10kb) Multiome | 186 | |
| chr5:1,930,629–1,931,989 | 131.2 kb | Distal (>10kb) Multiome | 233 | |
| chr5:2,038,286–2,039,379 | 238.9 kb | Distal (>10kb) Multiome | 517 |
Genomic view of the MRPL36 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.