Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL15 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 15q. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MRPL15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRPL15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRPL15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:52,939,106–52,942,189 | 1193.6 kb | Distal (>10kb) Multiome HiCAR | 558 | |
| chr8:53,842,551–53,843,618 | 292.1 kb | Distal (>10kb) Multiome | 936 | |
| chr8:53,879,185–53,882,655 | 255.3 kb | Distal (>10kb) Multiome | 721 | |
| chr8:54,021,584–54,023,157 | 112.8 kb | Distal (>10kb) Multiome | 965 | |
| chr8:54,101,305–54,102,633 | 33.3 kb | Distal (>10kb) Multiome | 744 | |
| chr8:54,134,624–54,135,508 | 47 bp | At TSS Multiome | 807 | |
| chr8:54,223,881–54,225,934 | 89.8 kb | Distal (>10kb) Multiome | 303 | |
| chr8:54,259,099–54,260,380 | 124.8 kb | Distal (>10kb) Multiome | 139 | |
| chr8:54,267,801–54,269,212 | 133.2 kb | Distal (>10kb) Multiome | 253 | |
| chr8:54,300,265–54,301,003 | 165.5 kb | Distal (>10kb) Multiome | 195 | |
| chr8:54,301,815–54,302,560 | 167.0 kb | Distal (>10kb) Multiome | 136 |
Genomic view of the MRPL15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.