Enables chromatin binding activity. Involved in several processes, including mitotic G2 DNA damage checkpoint signaling; positive regulation of protein kinase activity; and regulation of double-strand break repair. Located in Mre11 complex and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MRNIP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRNIP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRNIP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:179,559,012–179,560,188 | 299.2 kb | Distal (>10kb) Multiome | 624 | |
| chr5:179,622,406–179,625,135 | 236.1 kb | Distal (>10kb) Multiome | 1217 | |
| chr5:179,678,118–179,679,585 | 180.2 kb | Distal (>10kb) Multiome | 1007 | |
| chr5:179,698,113–179,699,498 | 160.1 kb | Distal (>10kb) Multiome | 1062 | |
| chr5:179,732,076–179,733,697 | 126.1 kb | Distal (>10kb) Multiome | 820 | |
| chr5:179,795,059–179,796,988 | 62.6 kb | Distal (>10kb) Multiome | 778 | |
| chr5:179,805,642–179,807,610 | 51.9 kb | Distal (>10kb) Multiome | 747 | |
| chr5:179,818,809–179,822,095 | 38.0 kb | Distal (>10kb) Multiome | 1243 | |
| chr5:179,858,283–179,859,465 | 52 bp | At TSS Multiome | 923 | |
| chr5:179,907,372–179,908,268 | 49.1 kb | Distal (>10kb) Multiome | 528 | |
| chr5:180,007,647–180,008,169 | 149.0 kb | Distal (>10kb) Multiome | 251 | |
| chr5:180,059,605–180,060,144 | 200.9 kb | Distal (>10kb) Multiome | 18 | |
| chr5:180,069,680–180,070,372 | 211.1 kb | Distal (>10kb) Multiome | 240 | |
| chr5:180,071,104–180,072,473 | 213.1 kb | Distal (>10kb) Multiome | 1084 | |
| chr5:180,090,117–180,091,054 | 231.6 kb | Distal (>10kb) Multiome | 575 |
Genomic view of the MRNIP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.