Enables identical protein binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MRFAP1L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRFAP1L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRFAP1L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:6,470,551–6,471,324 | 238.9 kb | Distal (>10kb) Multiome | 373 | |
| chr4:6,472,122–6,472,949 | 237.2 kb | Distal (>10kb) Multiome | 157 | |
| chr4:6,574,723–6,575,464 | 134.7 kb | Distal (>10kb) Multiome | 601 | |
| chr4:6,640,089–6,641,132 | 69.2 kb | Distal (>10kb) Multiome | 851 | |
| chr4:6,673,157–6,674,688 | 35.8 kb | Distal (>10kb) Multiome | 920 | |
| chr4:6,701,486–6,701,689 | 8.1 kb | Proximal (<10kb) | 78 | |
| chr4:6,709,388–6,710,099 | 17 bp | At TSS Multiome | 693 | |
| chr4:6,715,775–6,716,910 | 6.3 kb | Proximal (<10kb) Multiome | 822 | |
| chr4:6,782,106–6,784,027 | 72.7 kb | Distal (>10kb) Multiome | 886 | |
| chr4:6,908,950–6,910,715 | 199.8 kb | Distal (>10kb) Multiome | 820 | |
| chr4:6,986,472–6,987,825 | 277.3 kb | Distal (>10kb) Multiome | 762 | |
| chr4:7,007,023–7,007,815 | 297.6 kb | Distal (>10kb) Multiome | 59 |
Genomic view of the MRFAP1L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.