Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in melanocyte differentiation; melanosome transport; and phagosome maturation. Predicted to act upstream of or within developmental pigmentation. Predicted to be located in late endosome membrane and melanosome membrane. Predicted to be part of protein-containing complex. Predicted to be active in melanosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MREG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MREG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MREG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:215,905,935–215,906,837 | 107.1 kb | Distal (>10kb) Multiome | 76 | |
| chr2:216,006,306–216,006,632 | 6.9 kb | Proximal (<10kb) | 302 | |
| chr2:216,012,871–216,013,914 | 64 bp | At TSS Multiome | 664 | |
| chr2:216,023,120–216,023,356 | 9.6 kb | Proximal (<10kb) | 144 | |
| chr2:216,081,343–216,082,368 | 68.3 kb | Distal (>10kb) Multiome | 872 | |
| chr2:216,109,035–216,110,011 | 95.8 kb | Distal (>10kb) Multiome | 866 | |
| chr2:216,114,288–216,115,514 | 101.3 kb | Distal (>10kb) Multiome | 671 | |
| chr2:216,275,236–216,275,858 | 261.9 kb | Distal (>10kb) Multiome | 120 | |
| chr2:216,283,571–216,284,041 | 270.2 kb | Distal (>10kb) Multiome | 206 | |
| chr2:216,292,640–216,293,553 | 279.6 kb | Distal (>10kb) Multiome | 205 |
Genomic view of the MREG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.