Predicted to enable GPI anchor binding activity; GPI-mannose ethanolamine phosphate phosphodiesterase activity; and manganese ion binding activity. Involved in GPI anchor biosynthetic process. Located in Golgi apparatus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for MPPE1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MPPE1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MPPE1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:11,688,830–11,690,282 | 219.0 kb | Distal (>10kb) Multiome | 759 | |
| chr18:11,714,339–11,714,936 | 193.9 kb | Distal (>10kb) Multiome | 121 | |
| chr18:11,751,239–11,752,922 | 156.8 kb | Distal (>10kb) Multiome | 189 | |
| chr18:11,823,081–11,823,838 | 84.8 kb | Distal (>10kb) Multiome | 76 | |
| chr18:11,850,966–11,851,799 | 57.0 kb | Distal (>10kb) Multiome | 890 | |
| chr18:11,902,776–11,903,138 | 5.2 kb | Proximal (<10kb) | 55 | |
| chr18:11,908,184–11,909,142 | 144 bp | At TSS Multiome | 805 | |
| chr18:11,947,210–11,948,156 | 39.2 kb | Distal (>10kb) Multiome | 645 | |
| chr18:11,980,290–11,982,581 | 72.8 kb | Distal (>10kb) Multiome | 1002 | |
| chr18:12,038,383–12,039,391 | 130.7 kb | Distal (>10kb) Multiome | 700 | |
| chr18:12,076,413–12,076,882 | 168.3 kb | Distal (>10kb) Multiome | 129 |
Genomic view of the MPPE1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.